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# CITATION file created with {cffr} R package
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cff-version: 1.2.0
message: 'To cite package "BOP2FE" in publications use:'
type: software
license: MIT
title: 'BOP2FE: Bayesian Optimal Phase II Design with Futility and Efficacy Stopping
  Boundaries'
version: 1.0.3
doi: 10.32614/CRAN.package.BOP2FE
abstract: Bayesian optimal design with futility and efficacy stopping boundaries (BOP2-FE)
  is a novel statistical framework for single-arm Phase II clinical trials. It enables
  early termination for efficacy when interim data are promising, while explicitly
  controlling Type I and Type II error rates. The design supports a variety of endpoint
  structures, including single binary endpoints, nested endpoints, co-primary endpoints,
  and joint monitoring of efficacy and toxicity. The package provides tools for enumerating
  stopping boundaries prior to trial initiation and for conducting simulation studies
  to evaluate the design’s operating characteristics. Users can flexibly specify design
  parameters to suit their specific applications. For methodological details, refer
  to Xu et al. (2025) <https://doi.org/10.1080/10543406.2025.2558142>.
authors:
- family-names: Yimer
  given-names: Belay Birlie
  email: belayabyimer@gmail.com
- family-names: Xu
  given-names: Xinling
- family-names: Hashimoto
  given-names: Atsuki
- family-names: Homma
  given-names: Gosuke
- family-names: Takeda
  given-names: Kentaro
repository: https://belayb.r-universe.dev
repository-code: https://github.com/belayb/BOP2FE
commit: a208063b0e2de4d77c3544481bc99b7d24b24b05
url: https://github.com/belayb/BOP2FE
date-released: '2025-10-01'
contact:
- family-names: Yimer
  given-names: Belay Birlie
  email: belayabyimer@gmail.com