{ "_id": "6a102505acfb0bcc41c8e8a0", "Package": "BOP2FE", "Type": "Package", "Title": "Bayesian Optimal Phase II Design with Futility and Efficacy\nStopping Boundaries", "Version": "1.0.3", "Authors@R": "c(\nperson(\"Belay Birlie\", \"Yimer\", email = \"belayabyimer@gmail.com\", role = c(\"aut\", \"cre\")),\nperson(\"Xinling\", \"Xu\", role = \"aut\"),\nperson(\"Atsuki\", \"Hashimoto\", role = \"aut\"),\nperson(\"Gosuke\", \"Homma\", role = \"aut\"),\nperson(\"Kentaro\", \"Takeda\", role = \"aut\"))", "Description": "Bayesian optimal design with futility and efficacy\nstopping boundaries (BOP2-FE) is a novel statistical framework\nfor single-arm Phase II clinical trials. It enables early\ntermination for efficacy when interim data are promising, while\nexplicitly controlling Type I and Type II error rates. The\ndesign supports a variety of endpoint structures, including\nsingle binary endpoints, nested endpoints, co-primary\nendpoints, and joint monitoring of efficacy and toxicity. The\npackage provides tools for enumerating stopping boundaries\nprior to trial initiation and for conducting simulation studies\nto evaluate the design’s operating characteristics. Users can\nflexibly specify design parameters to suit their specific\napplications. For methodological details, refer to Xu et al.\n(2025) .", "BugReports": "https://github.com/belayb/BOP2FE/issues", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "RoxygenNote": "7.3.3", "Language": "en-US", "URL": "https://github.com/belayb/BOP2FE", "Repository": "https://belayb.r-universe.dev", "Date/Publication": "2025-10-01 10:42:01 UTC", "RemoteUrl": "https://github.com/belayb/bop2fe", "RemoteRef": "HEAD", "RemoteSha": "a208063b0e2de4d77c3544481bc99b7d24b24b05", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-13 09:43:49 UTC", "User": "root" }, "Author": "Belay Birlie Yimer [aut, cre],\nXinling Xu [aut],\nAtsuki Hashimoto [aut],\nGosuke Homma [aut],\nKentaro Takeda [aut]", "Maintainer": "Belay Birlie Yimer ", "MD5sum": "8b97fb9c71a1a8df152377aef5d4fe22", "_user": "belayb", "_type": "src", "_file": "BOP2FE_1.0.3.tar.gz", "_fileid": "b752eb6963d80d1893b4c32f0926f3b4a00fc98f7f30874dcb586e854986a72a", "_filesize": 574436, "_sha256": 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