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drugprepr - Prepare Electronic Prescription Record Data to Estimate Drug Exposure

Prepare prescription data (such as from the Clinical Practice Research Datalink) into an analysis-ready format, with start and stop dates for each patient's prescriptions. Based on Pye et al (2018) <doi:10.1002/pds.4440>.

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4.18 score 3 stars 5 scripts 259 downloads

BOP2FE - Bayesian Optimal Phase II Design with Futility and Efficacy Stopping Boundaries

Bayesian optimal design with futility and efficacy stopping boundaries (BOP2-FE) is a novel statistical framework for single-arm Phase II clinical trials. It enables early termination for efficacy when interim data are promising, while explicitly controlling Type I and Type II error rates. The design supports a variety of endpoint structures, including single binary endpoints, nested endpoints, co-primary endpoints, and joint monitoring of efficacy and toxicity. The package provides tools for enumerating stopping boundaries prior to trial initiation and for conducting simulation studies to evaluate the design’s operating characteristics. Users can flexibly specify design parameters to suit their specific applications. For methodological details, refer to Xu et al. (2025) <doi:10.1080/10543406.2025.2558142>.

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3.48 score 2 stars 1 dependents 2 scripts 299 downloads

BayesGmed - Bayesian Causal Mediation Analysis using 'Stan'

Performs parametric mediation analysis using the Bayesian g-formula approach for binary and continuous outcomes. The methodology is based on Comment (2018) <doi:10.5281/zenodo.1285275> and a demonstration of its application can be found at Yimer et al. (2022) <doi:10.48550/arXiv.2210.08499>.

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onetbbcpp

3.30 score 4 stars 4 scripts 342 downloads